Analysis of abdominal internal hernia with main manifestation of metabolic acidosis / 中国中西医结合急救杂志

Abdominal internal hernia is relatively rare in clinics, which is easily to be ignored and occur serious complications, mainly the obstruction of gastrointestinal tract, such as gastrointestinal ischemia and necrosis, that could be life-threatening. This article introduced one case with atypical abdominal pain as the first manifestation of the disease, then the main symptom was metabolic acidosis and treatment was carried out, and finally by surgery the diagnosis of abdominal internal hernia was confirmed and proper treatment given.

Identification of potential molecular mechanisms and candidate genes involved in the acute phase of myocardial infarction

Objective: This study used bioinformatics to determine genetic factors involved in progression of acute myocardial infarction [MI]

Materials and Methods: In this prospective study, gene expression profile GSE59867 was downloaded from the Gene Expression Omnibus database, which contained 46 normal samples obtained from stable coronary artery disease patients [n=46] who were without history of MI [control] and 390 samples from patients [n=111] who had evolving ST-segment elevation myocardial infarction [STEMI] as the MI group. These samples were divided into 4 groups based on time points. After identification of differentially expressed genes [DEGs], we conducted hierarchical clustering and functional enrichment analysis. Protein interaction and transcriptional regulation among DEGs were analysed

Results: We observed 8 clusters of DEGs that had a peak or a minimum at the t=1 time point according to gene expression levels. Upregulated DEGs showed significant enrichment in the biological process, single-organism cellular process, response to stimulus and stress, and osteoclast differentiation and lysosome. Downregulated DEGs enriched in the T-cell receptor signalling pathway and natural killer cell mediated cytotoxicity. We identified multiple genes, including signal transducer and activator of transcription 3 [STAT3]; LCK proto-oncogene, Src family tyrosine kinase [LCK]; and FYN proto-oncogene, Src family tyrosine kinase [FYN] from the protein-protein interaction [PPI] network and/or the transcriptional regulatory network

Conclusion: Cytokine-mediated inflammation, lysosome and osteoclast differentiation, and metabolism processes, as well as STAT3 may be involved in the acute phase of MI